CD14, new aspects of ligand and signal diversity

被引：142

作者：

Landmann, R

Müller, B

Zimmerli, W

机构：

[1] Univ Basel Hosp, Dept Res, Div Infect Dis, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Dept Internal Med, CH-4031 Basel, Switzerland

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 03期

关键词：

CD14; lipopolysaccharide; signaling;

D O I：

10.1016/S1286-4579(00)00298-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The glycosyl-phosphatidylinositol-linked glycoprotein CD14 is expressed in myeloid cells and serum. It binds Gram-negative and -positive bacterial cell wall components and endogenous phospholipids. Toll-like receptors, NF-KB and MAP kinases participate in CD14 signaling of inflammation. Alterations of CD14 in inflammatory diseases support a pathogenic role for this microbial receptor. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

收藏

页码：295 / 304

页数：10

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