The synthesis of imidazoline analogs of the Kainoid family

被引：8

作者：

Baumgartner, H ^{[1
]}

OSullivan, AC ^{[1
]}

机构：

[1] CIBA GEIGY AG,CH-4002 BASEL,SWITZERLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 08期

关键词：

D O I：

10.1016/S0040-4020(97)00005-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In an effort to mimic the anthelmintic and insecticidal activties of kainic 1 and domoic 2 acids with compounds of simpler structure and much easier accessibility, the highly functionalised imidazolines 4, 27, and 28 were prepared. This involved a synthesis of suitably protected beta-aminoglutamic acid derivatives as key intermediates, which were condensed with orthoesters and deprotected to yield the desired compounds. (C) 1997 Elsevier Science Ltd.

引用

页码：2775 / 2784

页数：10

共 38 条

[1] ABERHALDEN E, 1937, Z PHYSL CHEM, V247, P231
[2] Andruszkiewicz R, 1995, POL J CHEM, V69, P1615
[3] ATKINS H, 1938, J AM CHEM SOC, V60, P1328
[4] BAEYER A, 1873, ANN CHEM PHARM, V166, P325
[5] BAUER B, 1986, Patent No. 4593118
[6] BAUER BA, Patent No. 549891
[7] BIRKOFER L, 1964, LIEBIGS ANN CHEM, V677, P150
[8] Daigo K., 1959, YAKUGAKU ZASSHI, V79, P353
[9] Du Vigneaud V, 1942, J BIOL CHEM, V146, P0475
[10] Ring synthesis of pyromellit acid.
Feist, F
[J]. BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, 1911, 44 : 135 - 138

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