Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis)

被引：1537

作者：

Gaggelli, Elena

Kozlowski, Henryk

Valensin, Daniela

Valensin, Gianni

机构：

[1] Univ Siena, Dept Chem, I-53100 Siena, Italy

[2] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland

来源：

CHEMICAL REVIEWS | 2006年 / 106卷 / 06期

关键词：

D O I：

10.1021/cr040410w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This review covers copper homeostasis and its eventual link with copper involvement in different neurological disorders. Copper plays a dual role in producing reactive oxygen species: damaging the cells and eliciting antioxidant activity. Abnormal binding of metal ions to proteins or losing control over the copper homeostasis can result in disorders including neurodegenerative diseases. In addition to creating oxidative stress, copper, together with other metal ions influences protein aggregation processes that are critical in most of the neurodegenerative diseases.

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页码：1995 / 2044

页数：50

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