A 25 year adventure in the field of tachykinins

被引：58

作者：

Beaujouan, JC ^{[1
]}

Torrens, Y ^{[1
]}

Saffroy, M ^{[1
]}

Kernel, ML ^{[1
]}

Glowinski, J ^{[1
]}

机构：

[1] Coll France, INSERM, Chaire Neuropharmacol, F-75231 Paris 05, France

来源：

PEPTIDES | 2004年 / 25卷 / 03期

关键词：

tachykinins; substance P; tachykinin receptors; NK1NK2NK3; receptors; NK1 receptor subtypes; binding sites; septide-sensitive binding sites; autoradiography; biosynthesis; release; brain; biological activities;

D O I：

10.1016/j.peptides.2004.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several aspects of our 25 year adventure ill the field of tachykinins will be Successively described. They concern: substance P (SP) synthesis and release in the basal ganglia, the identification and pharmacological characterization of central tachykinin NK1, NK2 and NK3 binding, sites and their topographical distribution, the description of some new biological tests for corresponding receptors, the identification of tachykinin NK1 receptor subtypes or conformers sensitive to all endogenous tachykinins (substance P, neurokinin A (NKA), neurokinin B (NKB), neuropeptide gamma (NPgamma) and neuropeptide K (NPK)) and finally, the functional involvement of these receptors and their subtypes in tachykinin-induced regulations of dopamine and acetylcholine release in the striatum. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：339 / 357

页数：19

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