Cathepsin D is involved in the clearance of Alzheimer's beta-amyloid protein

被引：77

作者：

Hamazaki, H

机构：

[1] Department of Biology, Kitasato Univ. School of Medicine, Sagamihara

来源：

FEBS LETTERS | 1996年 / 396卷 / 2-3期

关键词：

Alzheimer's disease; beta-amyloid; amyloidosis; cathepsin D; rat brain; aspartic proteinase;

D O I：

10.1016/0014-5793(96)01087-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cerebral deposition of 39-42 residue amyloid beta-protein (A beta) is a histopathological characteristic of Alzheimer's disease. The present study is aimed at finding proteinases responsible for the intracellular clearance of A beta. The A beta degrading proteinase was purified from rat brain. Aminoterminal sequence analysis indicated the A beta-degrading proteinase was cathepsin D. Purified cathepsin D hydrolyzed A beta between Phe(19) and Phe(20). Cathepsin D is likely to be involved in the intracellular clearance of aggregatable A beta, since A beta fragments with Phe(20) at the amino-terminus have been reported to be secreted from several lines of cultured cells.

引用

页码：139 / 142

页数：4

共 15 条

[1] CLONING, SEQUENCE AND EXPRESSION OF RAT CATHEPSIN-D [J].