Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNFα-treated galactosamine-sensitized mice

被引:1
作者
Angermüller, S
Schümann, J
Fahimi, HD
Tiegs, G
机构
[1] Univ Heidelberg, Dept Anat & Cell Biol 2, D-06221 Heidelberg, Germany
[2] Univ Erlangen Nurnberg, Inst Expt & Clin Pharmacol & Toxicol, D-8520 Erlangen, Germany
来源
MECHANISMS OF CELL DEATH: THE SECOND ANNUAL CONFERENCE OF THE CELL DEATH SOCIETY | 1999年 / 887卷
关键词
D O I
10.1111/j.1749-6632.1999.tb07918.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The electron microscopical studies presented here show that characteristic morphological alterations in mitochondria are a very early hallmark of the hepatocellular apoptotic program, Before chromatin condensation occurs. the outer mitochondrial membrane is focally disrupted and the inner membrane protrudes through this gap forming a hernia, The demonstration of cytochrome oxidase in mitochondria revealed a very strong. activity in pre-apoptotic and apoptotic cells as well as in apoptotic bodies.
引用
收藏
页码:12 / 17
页数:6
相关论文
共 27 条
[1]   Pre-apoptotic alterations in hepatocytes of TNFα-treated galactosamine-sensitized mice [J].
Angermüller, S ;
Künstle, G ;
Tiegs, G .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1998, 46 (10) :1175-1183
[2]   SELECTIVE CYTOCHEMICAL-LOCALIZATION OF PEROXIDASE, CYTOCHROME-OXIDASE AND CATALASE IN RAT-LIVER WITH 3,3'-DIAMINOBENZIDINE [J].
ANGERMULLER, S ;
FAHIMI, HD .
HISTOCHEMISTRY, 1981, 71 (01) :33-44
[3]   Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo [J].
Castedo, M ;
Macho, A ;
Zamzami, N ;
Hirsch, T ;
Marchetti, P ;
Uriel, J ;
Kroemer, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (12) :3277-3284
[4]   PROTECTIVE EFFECT OF N-ACETYLCYSTEINE IN TUMOR NECROSIS FACTOR-ALPHA-INDUCED APOPTOSIS IN U937 CELLS - THE ROLE OF MITOCHONDRIA [J].
COSSARIZZA, A ;
FRANCESCHI, C ;
MONTI, D ;
SALVIOLI, S ;
BELLESIA, E ;
RIVABENE, R ;
BIONDO, L ;
RAINALDI, G ;
TINARI, A ;
MALORNI, W .
EXPERIMENTAL CELL RESEARCH, 1995, 220 (01) :232-240
[5]  
ENARI M, 1995, EMBO J, V14, P5201, DOI 10.1002/j.1460-2075.1995.tb00204.x
[6]   BCL-2 IS AN INNER MITOCHONDRIAL-MEMBRANE PROTEIN THAT BLOCKS PROGRAMMED CELL-DEATH [J].
HOCKENBERY, D ;
NUNEZ, G ;
MILLIMAN, C ;
SCHREIBER, RD ;
KORSMEYER, SJ .
NATURE, 1990, 348 (6299) :334-336
[7]   BCL2 PROTEIN IS TOPOGRAPHICALLY RESTRICTED IN TISSUES CHARACTERIZED BY APOPTOTIC CELL-DEATH [J].
HOCKENBERY, DM ;
ZUTTER, M ;
HICKEY, W ;
NAHM, M ;
KORSMEYER, SJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :6961-6965
[8]   BCL-2 BLOCKS APOPTOSIS IN CELLS LACKING MITOCHONDRIAL-DNA [J].
JACOBSON, MD ;
BURNE, JF ;
KING, MP ;
MIYASHITA, T ;
REED, JC ;
RAFF, MC .
NATURE, 1993, 361 (6410) :365-369
[9]   APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS [J].
KERR, JFR ;
WYLLIE, AH ;
CURRIE, AR .
BRITISH JOURNAL OF CANCER, 1972, 26 (04) :239-+
[10]  
Kimura K, 1997, J PATHOL, V181, P235