IL-10 as a mediator in the HPA axis and brain

被引:94
作者
Smith, EM [1 ]
Cadet, P
Stefano, GB
Opp, MR
Hughes, TK
机构
[1] Univ Texas, Med Branch, Dept Psychiat & Behav Sci, Galveston, TX 77555 USA
[2] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA
[3] SUNY Coll Old Westbury, Neurosci Res Inst, Old Westbury, NY 11568 USA
关键词
neuroendocrine hormones; neuroimmunomodulation; cytokines; lymphocytes; pituitary;
D O I
10.1016/S0165-5728(99)00206-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Certain functional interactions between the nervous, endocrine, and immune systems are mediated, by cytokines. The pro-inflammatory cytokines, interleukin-l (IL-I) and tumor necrosis factor (TNF) were among the first to be recognized in this regard. A modulator of these cytokines, IL-10, has been shown to have a wide range of activities in the immune system; in this review, wa describe its production and actions in the hypothalamic-pituitary-adrenal (HPA) axis. IL-10 is produced in pituitary, hypothalamic, and neural tissues in addition to lymphocytes. IL-10 enhances corticotropin releasing factor (CRF) and corticotropin (ACTH) production in hypothalamic and pituitary tissues, respectively. Further downstream in the HPA axis endogenous IL-10 has the potential to contribute to regulation of glucocorticosteroid production both tonically and following stressors. Our studies and those of others reviewed here indicate that IL-10 may be an important endogenous regulator in IIPA axis activity and in CNS pathologies such as multiple sclerosis. Thus, in addition to its more widely recognized role in immunity, IL-10's neuroendocrine activities described here point to its role as an important regulator in communication between the immune and neuroendocrine systems. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:140 / 148
页数:9
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