CD28- T cells: their role in the age-associated decline of immune function

被引：488

作者：

Weng, Nan-ping ^{[1
]}

Akbar, Arne N. ^{[2
]}

Goronzy, Jorg ^{[3
]}

机构：

[1] NIA, Immunol Lab, NIH, Baltimore, MD 21224 USA

[2] UCL, Dept Immunol, London W1T 4JF, England

[3] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30322 USA

来源：

TRENDS IN IMMUNOLOGY | 2009年 / 30卷 / 07期

关键词：

DNA METHYLATION; TELOMERASE ACTIVITY; GENE-EXPRESSION; DOWN-REGULATION; REPLICATIVE SENESCENCE; LYMPHOCYTE DEVELOPMENT; REGULATED EXPRESSION; SHORTENED TELOMERES; CLONAL EXPANSIONS; IN-VIVO;

D O I：

10.1016/j.it.2009.03.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The accumulation of CD28(-) T cells, particularly within the CD8 subset, is one of the most prominent changes during T-cell homeostasis and function associated with aging in humans. CD28, a major co-stimulatory receptor, is responsible for the optimal anti g en-mediated T-cell activation, proliferation and survival of T cells. CD28(-) T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions. Gene expression analyses reveal profound changes of CD28(-) T cells in comparison to their CD28(+) counterparts and corroborate their functional differences. Here we review recent advances in our understanding of CD28(-) T cells and their role in the age-associated decline of immune function.

引用

页码：306 / 312

页数：7

共 86 条

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