Potential hepatoprotective activity of ononitol monohydrate isolated from Cassia tora L. on carbon tetrachloride induced hepatotoxicity in wistar rats

被引：58

作者：

Dhanasekaran, Muniyappan ^{[1
]}

Ignacimuthu, Savarimuthu ^{[1
]}

Agastian, Paul ^{[2
]}

机构：

[1] Loyola Coll, Entomol Res Inst, Div Ethnopharmacol, Madras 600034, Tamil Nadu, India

[2] Loyola Coll, Dept Plant Biol & Biotechnol, Madras 600034, Tamil Nadu, India

来源：

PHYTOMEDICINE | 2009年 / 16卷 / 09期

关键词：

Ononitol monohydrate; Cassia tora; Carbon tetrachloride; Hepatoprotective; LIPID-PEROXIDATION; ASSAY; CELLS;

D O I：

10.1016/j.phymed.2009.02.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Ononitol monohydrate, structurally similar to glycoside was isolated from Cassia tora L. leaves. Fifty Male rats were divided into five groups. Group I served as normal control. Group II, III and IV rats were induced hepatotoxicity by CCl4 administering single dose Of CCl4 on 8th day only. Group III was treated with ononitol monohydrate (20 mg/kg body weight) and group IV was treated with reference drug silymarin (20 mg/kg body weight) both dissolved in corn oil and administering for 8 days. Ononitol monohydrate with corn oil alone was given for 8 days (group V). At the end of the experimental period all the animals were sacrificed and analyzed for biochemical parameters to assess the effect of ononitol monohydrate treatment in CCl4 induced hepatotoxicity. In in vivo study, ononitol monohydrate decreased the levels of serum transaminase, lipid peroxidation and TNF-alpha but increased the levels of antioxidant and hepatic glutathione enzyme activities. Compared with reference drug silymarin ononitol monohydrate possessesed high hepatoprotective activity. Histopathological results also suggested the hepatoprotective activity of ononitol monohydrate with no adverse effect. Hence we conclude that ononitol monohydrate is a potent hepatoprotective agent. (c) 2009 Elsevier GmbH. All rights reserved.

引用

页码：891 / 895

页数：5

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