Atorvastatin Modulates Th1/Th2 Response in Patients With Chronic Heart Failure

被引：72

作者：

Cheng, Xiang ^{[1
]}

Ding, Yingjun ^{[1
]}

Xia, Chunyan ^{[1
]}

Tang, Tingting ^{[1
]}

Yu, Xian ^{[1
]}

Xie, Jiangjiao ^{[1
]}

Liao, Mengyang ^{[1
]}

Yao, Rui ^{[1
]}

Chen, Yong ^{[1
]}

Wang, Min ^{[1
]}

Liao, Yu-Hua ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Inst Cardiol, Lab Cardiovasc Immunol,Tongji Med Coll, Wuhan 430022, Peoples R China

来源：

JOURNAL OF CARDIAC FAILURE | 2009年 / 15卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Chronic heart failure; T lymphocyte; helper; HMG-CoA reductase inhibitor; T-CELLS; IMBALANCE; STATINS; ENCEPHALOMYELITIS; INFLAMMATION; ACTIVATION; PARALYSIS; PROMOTES; MARKERS;

D O I：

10.1016/j.cardfail.2008.10.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

dBackground: The T-helper (Th)1/Th2 imbalance has been demonstrated to be involved in chronic heart failure (CHF). We sought to determine whether atorvastatin exhibited any effect on CHF through modulating the Th1/Th2 response. Methods and Results: We measured serum concentrations of interleukin(IL)-12, -18, interferon(IFN)-gamma, IL-4. and IL-10 from 20 controls and 72 patients with nonischemic CHF by enzyme-linked immunosorbent assay. To investigate the effect of atorvastatin in vivo, CHF patients were either classified into a Usual therapy group (n = 35) or usual therapy Plus atorvastatin ( 10 mg/day) group (it = 37). Patient serum levels of IFN-gamma and IL-4 were measured at time of admission and 2 weeks after treatment. Peripheral blood mononuclear cells from patients of CHF g-roup were Cultured in the presence or absence of atorvastatin (0, 0.4, 1, and 4 mu mol/L) in vitro, and IFN-gamma and IL-4 levels were detected. Serum levels of IL-12, IL-18, and IFN-gamma were significantly higher in the CHF group than in the control group. The levels of IFN-gamma and the ratios of IFN-gamma:IL-4 were significantly decreased with atorvastatin treatment both in vivo and in vitro, whereas levels of IL-4 did not differ significantly. Conclusions: Th1 polarization exists in patients with CHF. and atorvastatin can modulate the Th1/Th2 response through inhibiting Th I cytokine production. (J Cardiac Fail 2009;15:158-162)

引用

页码：158 / 162

页数：5

共 26 条

[1] Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin [J].