Antiplasmodial activities and cytotoxic effects of aqueous extracts and sesquiterpene lactones from Neurolaena lobata

被引：70

作者：

Francois, G

Passreiter, CM

Woerdenbag, HJ

VanLooveren, M

机构：

[1] UNIV DUSSELDORF, INST PHARMAZEUT BIOL, D-40225 DUSSELDORF, GERMANY

[2] INST TROP MED PRINCE LEOPOLD, PROTOZOOL LAB, B-2000 ANTWERP, BELGIUM

[3] UNIV GRONINGEN, CTR PHARM, DEPT PHARMACEUT BIOL, 9713 AW GRONINGEN, NETHERLANDS

来源：

PLANTA MEDICA | 1996年 / 62卷 / 02期

关键词：

Neurolaena lobata (L) R Br; Asteraceae; cytotoxicity; malaria; Plasmodium falciparum; sesquiterpene lactones;

D O I：

10.1055/s-2006-957833

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Aqueous and lipophilic extracts of Neurolaena lobata (Asteraceae), obtained from Guatemala, were tested against Plasmodium falciparum in vitro. Moreover, sesquiterpene lactones, of the germacranolide and furanoheliangolide type, isolated from N. lobata, were shown to be active against P. falciparum in vitro. In addition to their antiplasmodial activity, their cytotoxic effects on human carcinoma cell lines were evaluated. Structure-activity relationships are discussed.

引用

页码：126 / 129

页数：4

共 27 条

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MAYA MEDICINAL-PLANTS OF SAN-JOSE-SUCCOTZ, BELIZE [J].