Minimal introns are not "junky"

被引：61

作者：

Yu, J ^{[1
]}

Yang, ZY

Kibukawa, M

Paddock, M

Passey, DA

Wong, GKS

机构：

[1] Univ Washington, Genome Ctr, Dept Med, Seattle, WA 98195 USA

[2] Zhejiang Univ, Key Lab Bioinformat Zhejiang Province, Inst Bioinformat, Hangzhou Genom Inst, Hangzhou 310007, Peoples R China

[3] Chinese Acad Sci, Ctr Genom & Bioinformat, Beijing Genom Inst, Beijing 101300, Peoples R China

[4] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

GENOME RESEARCH | 2002年 / 12卷 / 08期

关键词：

D O I：

10.1101/gr.224602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intron-size distributions for most multicellular (and some unicellular) eukaryotes have a sharp peak at their. minimal intron" size. Across the human population, these minimal introns exhibit an abundance of insertion-deletion polymorphisms, the effect of which is to maintain their optimal size. We argue that minimal introns affect function by enhancing the rate at which mRNA is exported from the cell nucleus.

引用

页码：1185 / 1189

页数：5

共 35 条

[1] A handful of intron-containing genes produces the lion's share of yeast mRNA [J].

Ares, M ;

Grate, L ;

Pauling, MH .

RNA, 1999, 5 (09) :1138-1139

[2] EXON RECOGNITION IN VERTEBRATE SPLICING [J].

BERGET, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (06) :2411-2414

[3] Isochores and the evolutionary genomics of vertebrates [J].

Bernardi, G .

GENE, 2000, 241 (01) :3-17

[4] Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases [J].

Blencowe, BJ .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (03) :106-110

[5] Characterization of single-nucleotide polymorphisms in coding regions of human genes [J].

Cargill, M ;

Altshuler, D ;

Ireland, J ;

Sklar, P ;

Ardlie, K ;

Patil, N ;

Lane, CR ;

Lim, EP ;

Kalyanaraman, N ;

Nemesh, J ;

Ziaugra, L ;

Friedland, L ;

Rolfe, A ;

Warrington, J ;

Lipshutz, R ;

Daley, GQ ;

Lander, ES .

NATURE GENETICS, 1999, 22 (03) :231-238

[6] Genetic recombination - Intron size and natural selection [J].

Carvalho, AB ;

Clark, AG .

NATURE, 1999, 401 (6751) :344-344

[7] A GENERIC INTRON INCREASES GENE-EXPRESSION IN TRANSGENIC MICE [J].

CHOI, T ;

HUANG, M ;

GORMAN, C ;

JAENISCH, R .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (06) :3070-3074

[8] A DNA polymorphism discovery resource for research on human genetic variation [J].

Collins, FS ;

Brooks, LD ;

Chakravarti, A .

GENOME RESEARCH, 1998, 8 (12) :1229-1231

[9] Nuclear RNA export pathways [J].

Cullen, BR .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (12) :4181-4187

[10] The highly reduced genome of an enslaved algal nucleus [J].

Douglas, S ;

Zauner, S ;

Fraunholz, M ;

Beaton, M ;

Penny, S ;

Deng, LT ;

Wu, XN ;

Reith, M ;

Cavalier-Smith, T ;

Maier, UG .

NATURE, 2001, 410 (6832) :1091-1096

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