Role of brain biopsy in the management of focal brain lesions in HIV-infected patients

被引：37

作者：

Antinori, A

Ammassari, A

Luzzati, R

Castagna, A

Maserati, R

Rizzardini, G

Ridolfo, A

Fasan, M

Vaccher, E

Landonio, G

Scerrati, M

Rocca, A

Butti, G

Nicolato, A

Lazzarin, A

Tirelli, U

机构：

[1] Univ Cattolica Sacro Cuore, Dept Infect Dis, I-00168 Rome, Italy

[2] IRCCS L Spallanzani, Dept Infect Dis, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Dept Neurosurg, I-00168 Rome, Italy

[4] Univ Hosp Verona, Inst Immunol & Infect Dis, Verona, Italy

[5] Univ Hosp Verona, Dept Neurosurg, Verona, Italy

[6] Hosp San Raffaele, IRCCS, Dept Infect Dis, I-20132 Milan, Italy

[7] Hosp San Raffaele, IRCCS, Dept Neurosurg, I-20132 Milan, Italy

[8] Policlin San Matteo, IRCCS, Dept Infect Dis, I-27100 Pavia, Italy

[9] Policlin San Matteo, IRCCS, Dept Neurosurg, I-27100 Pavia, Italy

[10] L Sacco Hosp Vialba, Dept Infect Dis 1, I-20157 Milan, Italy

[11] L Sacco Hosp Vialba, Dept Infect Dis 3, I-20157 Milan, Italy

[12] Univ Milan, Inst Infect Dis & Trop Med, L Sacco Hosp, Milan, Italy

[13] Ctr Riferimento Oncol, Div Med Oncol & AIDS, IRCCS, I-33081 Aviano, Italy

[14] Osped Niguarda Ca Granda, Dept Infect Dis, Milan, Italy

来源：

NEUROLOGY | 2000年 / 54卷 / 04期

关键词：

brain biopsy; focal brain lesion; HIV;

D O I：

10.1212/WNL.54.4.993

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this multicenter, retrospective study of 160 brain biopsies in the assessment of HN-related focal brain lesions, diagnostic sensitivity was acceptable (87%), but the procedure carried considerable morbidity (7.5%) and mortality (3.1%). Moreover, it is not always possible to initiate the changes in therapy indicated by the results, and overall survival remains poor, with a median of 2 months. Criteria for brain biopsy for the diagnosis of focal brain lesions should be redefined to include selected patients for whom a less invasive approach does not yield a definitive diagnosis.

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收藏

页码：993 / 997

页数：5

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