The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals

被引：216

作者：

He, Ying ^{[1
]}

Jones, Christopher R. ^{[2
]}

Fujiki, Nobuhiro ^{[3
]}

Xu, Ying ^{[1
]}

Guo, Bin ^{[4
]}

Holder, Jimmy L., Jr. ^{[1
]}

Rossner, Moritz J. ^{[5
]}

Nishino, Seiji ^{[3
]}

Fu, Ying-Hui ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

[2] Univ Utah, Dept Neurol, Salt Lake City, UT 84132 USA

[3] Stanford Univ, Sleep & Circadian Neurobiol Lab, Palo Alto, CA 94304 USA

[4] Univ Calif Berkeley, Berkeley, CA 94720 USA

[5] Max Planck Inst Expt Med, D-37075 Gottingen, Germany

来源：

SCIENCE | 2009年 / 325卷 / 5942期

关键词：

PHASE SYNDROME; MOLECULAR CLOCK; MUSHROOM BODIES; MUTANT MICE; DROSOPHILA; EXPRESSION; MUTATION; CONSEQUENCES; NEUROBIOLOGY; DEPRIVATION;

D O I：

10.1126/science.1174443

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sleep deprivation can impair human health and performance. Habitual total sleep time and homeostatic sleep response to sleep deprivation are quantitative traits in humans. Genetic loci for these traits have been identified in model organisms, but none of these potential animal models have a corresponding human genotype and phenotype. We have identified a mutation in a transcriptional repressor (hDEC2-P385R) that is associated with a human short sleep phenotype. Activity profiles and sleep recordings of transgenic mice carrying this mutation showed increased vigilance time and less sleep time than control mice in a zeitgeber time- and sleep deprivation-dependent manner. These mice represent a model of human sleep homeostasis that provides an opportunity to probe the effect of sleep on human physical and mental health.

引用

页码：866 / 870

页数：5

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