The role of the proximal ligand in heme enzymes

被引：240

作者：

Poulos, TL ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,DEPT PHYSIOL & BIOPHYS,IRVINE,CA 92697

来源：

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 1996年 / 1卷 / 04期

关键词：

D O I：

10.1007/s007750050064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several new heme enzyme crystal structures have revealed similarities and differences in the local environment of the proximal heme ligand. This information, together with protein engineering studies, has provided important advances in understanding the role of the proximal ligand in heme enzyme catalysis. These advances include the ligand's role in the O-O bond cleavage reaction, stabilization of the Fe(IV) = O intermediate and control of the heme iron redox potential.

引用

页码：356 / 359

页数：4

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