Stereocontrolled functionalization in acyclic systems by exploiting internal 1,2-asymmetric induction - Generation of polypropionate and related motifs

被引：44

作者：

Hanessian, S

Gai, YH

Wang, WG

机构：

[1] Department of Chemistry, Université de Montréal, Montreal, Que. H3C 3J7, C.P. 6128, Succ. Centre-ville

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 42期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0040-4039(96)01753-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conjugate organocuprate additions to alpha,beta-unsaturated esters that have a gamma-ether substitutent take place with high anti-selectivity. potassium ester enolates can react with electrophiles to give the corresponding alpha-hydroxy alpha-alkyl, and alpha-azido esters with an overall anti/syn orientation of three vicinal groups relative to the initial resident chiral center. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：7473 / 7476

页数：4

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[1]

[Anonymous], TOTAL SYNTHESIS NATU

[2]

[Anonymous], [No title captured]

[3]

Collins A.N., 1992, CHIRALITY IND

[4]

Corey E.J., 1989, The Logic of Chemical Synthesis