Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone derivatives

被引：21

作者：

Kanno, O ^{[1
]}

Miyauchi, M ^{[1
]}

Kawamoto, I ^{[1
]}

机构：

[1] Sankyo Co Ltd, Med Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

来源：

HETEROCYCLES | 2000年 / 53卷 / 01期

关键词：

D O I：

10.3987/COM-99-8689

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient syntheses of (S)-4-hydroxy-2-pyrrolidinone ((S)-2) and (R)-4-acetylthio-2-pyrrolidinone (5), which are key intermediates of oral carbapenem CS-834, were studied. The most efficient route to (S)-2 from (S)-3-hydroxybutyrolactone (8) was accomplished in high yield via (S)-N-allyl-3-(1-ethoxy)ethoxy-4-hydroxybutyramide (14).

引用

页码：173 / 181

页数：9

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