Is LRIG1 a tumour suppressor gene at chromosome 3p14.3?

被引：81

作者：

Hedman, H ^{[1
]}

Nilsson, J ^{[1
]}

Guo, DS ^{[1
]}

Henriksson, R ^{[1
]}

机构：

[1] Univ Umea Hosp, Dept Radiat Sci & Oncol, S-90185 Umea, Sweden

来源：

ACTA ONCOLOGICA | 2002年 / 41卷 / 04期

关键词：

D O I：

10.1080/028418602760169398

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The LRIG1 gene (formerly LIG-1), recently cloned by us, displays structural similarities to the Drosophila Kek 1 gene. Kek 1 encodes a cell surface protein, Kekkon-1, which inhibits epidermal growth factor receptor-mediated signalling. We localized the LRIG1 gene to chromosome band 3p14.3, a region known to be deleted in various human cancers. In the present study LRIG1 gene expression was examined in different tumour cell lines and corresponding normal tissues by real-time RT-PCR. In many tumour cell lines, LRIG1 expression appeared absent or was down regulated compared to corresponding normal tissues. The results are consistent with LRIG1 being a tumour suppressor gene in humans. However, further studies are justified to elucidate the explicit role of LRIG1 as a negative regulator of oncogenesis.

引用

页码：352 / 354

页数：3

共 8 条

[1] The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis [J].

Ghiglione, C ;

Carraway, KL ;

Amundadottir, LT ;

Boswell, RE ;

Perrimon, N ;

Duffy, JB .

CELL, 1999, 96 (06) :847-856

[2] DNA copy number losses in human neoplasms [J].

Knuutila, S ;

Aalto, Y ;

Autio, K ;

Björkqvist, AM ;

El-Rifai, W ;

Hemmer, S ;

Huhta, T ;

Kettunen, E ;

Kiuru-Kuhlefelt, S ;

Larramendy, ML ;

Lushnikova, T ;

Monni, O ;

Pere, H ;

Tapper, J ;

Tarkkanen, M ;

Varis, A ;

Wasenius, VM ;

Wolf, M ;

Zhu, Y .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (03) :683-694

[3]

MITTELMAN F, 2001, MITTELMAN DATABASE C

[4] The Drosophila kekkon genes: Novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS [J].

Musacchio, M ;

Perrimon, N .

DEVELOPMENTAL BIOLOGY, 1996, 178 (01) :63-76

[5]

NILSSON J, 2001, BIOCHEM BIOPH RES CO, V284, P31

[6] The type III epidermal growth factor receptor mutation - Biological significance and potential target for anti-cancer therapy [J].

Pedersen, MW ;

Meltorn, M ;

Damstrup, L ;

Poulsen, HS .

ANNALS OF ONCOLOGY, 2001, 12 (06) :745-760

[7]

SUZUKI Y, 1996, J BIOL CHEM, V271, P225

[8]

Yarden Y, 2001, EUR J CANCER, V37, pS3

← 1 →