Hyperechogenicity of the substantia nigra in healthy controls is related to MRI changes and to neuronal loss as determined by F-Dopa PET

被引：43

作者：

Behnke, S. ^{[1
]}

Schroeder, U. ^{[1
]}

Dillmann, U. ^{[1
]}

Buchholz, H. G. ^{[5
]}

Schreckenberger, M. ^{[5
]}

Fuss, G. ^{[1
]}

Reith, W. ^{[2
]}

Berg, D. ^{[3
,4
]}

Krick, C. M. ^{[2
]}

机构：

[1] Univ Hosp Saarland, Dept Neurol, D-66421 Homburg Saar, Germany

[2] Univ Hosp Saarland, Dept Neuroradiol, D-66421 Homburg, Germany

[3] Univ Tubingen, Dept Neurodegenerat, Ctr Neurol, D-72076 Tubingen, Germany

[4] Univ Tubingen, Hertie Inst Clin Brain Res, D-72076 Tubingen, Germany

[5] Johannes Gutenberg Univ Mainz, Dept Nucl Med, D-55131 Mainz, Germany

来源：

NEUROIMAGE | 2009年 / 47卷 / 04期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; BRAIN PARENCHYMA SONOGRAPHY; IN-VIVO DETECTION; PARKINSONS-DISEASE; TRANSCRANIAL SONOGRAPHY; DOPAMINERGIC FUNCTION; IRON CONTENT; ECHOGENICITY; SYSTEM; SPECT;

D O I：

10.1016/j.neuroimage.2009.05.072

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transcranial ultrasound (TCS) has been shown to reveal hyperechogenicity of the substantia nigra (SN) in Parkinsonian patients and in about 10% of healthy controls. It is hypothesized that SN hyperechogenicity in healthy subjects is a vulnerability marker for idiopathic Parkinson's disease (IPD). Although there is strong evidence that the echomarker results from increased local iron content, the exact pathophysiological mechanisms remain incompletely understood. Thus, prognostic impact can only be estimated. We examined 14 subjects with SN hyperechogenicity (SN+) (7 IPD patients and 7 controls) and 7 healthy controls without the echomarker (SN-) by a magnetic resonance imaging method (MRI: T2 relaxation times) known to reveal tissue inhomogeneity following abnormal iron content and by F-Dopa PET to assess nigrostriatal function. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1237 / 1243

页数：7

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