Animal models of oxidative stress, aging, and therapeutic antioxidant interventions

被引：72

作者：

Melov, S ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2002年 / 34卷 / 11期

关键词：

oxidative stress; antioxidants; aging; mitochondria;

D O I：

10.1016/S1357-2725(02)00086-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative stress is a ubiquitous phenomena in all cell types, and it is primarily produced in mitochondria which are essential for multicellular life. Oxidative stress targets can be wide ranging and include nucleic acids and a variety of macromolecules. This review discusses the role of oxidative stress in the context of animal models, focusing in particular on animal models of aging, as well as the development of a new class of therapeutic small molecular weight antioxidants that have proven effective in extending the lifespan of a simple invertebrate nematode. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1395 / 1400

页数：6

共 41 条

[1]

[Anonymous], FREE RADICALS BIOL M

[2]

Baker K, 1998, J PHARMACOL EXP THER, V284, P215

[3] SALEN-MANGANESE COMPLEXES ARE SUPEROXIDE DISMUTASE-MIMICS [J].