Diffusion-weighted imaging in Huntington's disease

被引：39

作者：

Seppi, Klaus ^{[1
]}

Schocke, Michael F. H.

Mair, Katherina J.

Esterhammer, Regina

Weirich-Schwaiger, Helga

Utermann, Barbara

Egger, Karl

Brenneis, Christian

Granata, Roberta

Boesch, Sylvia

Poewe, Werner

Wenning, Gregor K.

机构：

[1] Innsbruck Med Univ, Dept Neurol, Innsbruck, Austria

[2] Innsbruck Med Univ, Dept Radiol 1, Innsbruck, Austria

[3] Innsbruck Med Univ, Inst Med Biol & Human Genet, Innsbruck, Austria

来源：

MOVEMENT DISORDERS | 2006年 / 21卷 / 07期

关键词：

Huntington's disease; striatum; magnetic resonance imaging; diffusion-weighted imaging;

D O I：

10.1002/mds.20868

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder that results from an expanded trinucleotide (CAG) repeat on the huntingtin gene. Neurodegeneration in HD affects most prominently the basal ganglia. Therefore, diffusivity was obtained in the basal ganglia and thalamus of 29 patients with early HD and 27 healthy volunteers by means of the trace of the diffusion tensor (Trace(D)). Putaminal, caudate, pallidal, and thalamic Trace(D) values were increased in patients with HD compared with controls. Increased diffusivity in the putamen and caudate nucleus correlated with global functional impairment, CAG repeat length, as well as bicaudate ratio. Diffusion-weighted imaging appears to be a promising surrogate marker for disease severity in HD. Sensitivity to change remains to be established longitudinally. (C) 2006 Movement Disorder Society.

引用

页码：1043 / 1047

页数：5

共 36 条

[1]

[11C]raclopride-PET studies of the Huntington's disease rate of progression:: Relevance of the trinucleotide repeat length [J].