Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

被引:24
作者
Boger, DL
Haynes, NE
Warren, MS
Gooljarsingh, LT
Ramcharan, J
Kitos, PA
Benkovic, SJ
机构
[1] PENN STATE UNIV, DEPT CHEM, UNIVERSITY PK, PA 16802 USA
[2] UNIV KANSAS, DEPT BIOCHEM, LAWRENCE, KS 66045 USA
关键词
D O I
10.1016/S0968-0896(97)00121-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:1831 / 1838
页数:8
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