The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders

被引：150

作者：

Faber, Scott ^{[1
]}

Zinn, Gregory M. ^{[2
]}

Kern, John C., II ^{[3
]}

Kingston, H. M. Skip ^{[2
]}

机构：

[1] Childrens Inst, Pittsburgh, PA 15217 USA

[2] Duquesne Univ, Dept Chem & Biochem, Pittsburgh, PA 15219 USA

[3] Duquesne Univ, Dept Math & Comp Sci, Pittsburgh, PA 15219 USA

来源：

BIOMARKERS | 2009年 / 14卷 / 03期

关键词：

Plasma zinc; serum copper ratio; zinc deficiency; metallothionein system dysfunction; mercury; autistic disorder; pervasive developmental disorder-NOS; Asperger's syndrome; ENVIRONMENTAL MERCURY RELEASE; NEURODEVELOPMENTAL DISORDERS; ENZYME-ACTIVITIES; ZINC-DEFICIENCY; IN-VITRO; METALLOTHIONEIN; METABOLISM; PORPHYRINURIA; EXPRESSION; TOXICITY;

D O I：

10.1080/13547500902783747

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The frequency of zinc deficiency, copper toxicity and low zinc/copper in children with autism spectrum disorders (ASDs) may indicate decrement in metallothionein system functioning. A retrospective review of plasma zinc, serum copper and zinc/copper was performed on data from 230 children with autistic disorder, pervasive developmental disorder-NOS and Asperger's syndrome. The entire cohort's mean zinc level was 77.2 g dl-1, mean copper level was 131.5 g dl-1, and mean Zn/Cu was 0.608, which was below the 0.7 cut-off of the lowest 2.5% of healthy children. The plasma zinc/serum copper ratio may be a biomarker of heavy metal, particularly mercury, toxicity in children with ASDs.

引用

页码：171 / 180

页数：10

共 61 条

[1] Mercury in first-cut baby hair of children with autism versus typically-developing children [J].

Arizona State University, AZ, United States ;

不详 ;

不详 .

Toxicol. Environ. Chem., 2008, 4 (739-753) :739-753

[2] Mercury, lead, and zinc in baby teeth of children with autism versus controls [J].

Adams, James B. ;

Romdalvik, Jane ;

Ramanujam, V. M. Sadagopa ;

Legator, Marvin S. .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2007, 70 (11-12) :1046-1051

[3] Regulation of metallothionein gene expression by oxidative stress and metal ions [J].

Andrews, GK .

BIOCHEMICAL PHARMACOLOGY, 2000, 59 (01) :95-104

[4]

Arredondo Miguel, 2005, Molecular Aspects of Medicine, V26, P313, DOI 10.1016/j.mam.2005.07.010

[5] The functional significance of brain metallothioneins [J].

Aschner, M .

FASEB JOURNAL, 1996, 10 (10) :1129-1136

[6] Metallothioneins: Mercury species-specific induction and their potential role in attenuating neurotoxicity [J].

Aschner, Michael ;

Syversen, Tore ;

Souza, Diogo O. ;

Rocha, Joao B. T. .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2006, 231 (09) :1468-1473

[7]

Ashwood E.R., 2004, ARUP's Guide to Pediatric Clinical Laboratory Testing: Testing Interpretation, Utilization, and Age-Specific Reference Intervals, VThird

[8] Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair [J].