Molecular basis of resistance displayed by highly ciprofloxacin-resistant Salmonella enterica serovar Typhi in Bangladesh

被引：25

作者：

Saha, Samir K. ^{[1
]}

Darmstadt, Gary L.

Baqui, Abdullah H.

Crook, Derrick W.

Islam, M. Nurul

Islam, Maksuda

Hossain, Maqsud

El Arifeen, Shams

Santosham, Mathuram

Black, Robert E.

机构：

[1] Dhaka Shishu Childrens Hosp, Dept Microbiol, Bangladesh Inst Child Hlth, Dhaka 1207, Bangladesh

[2] Johns Hopkins Univ, Dept Int Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[3] Univ Oxford, Oxford OX1 2JD, England

[4] ICDDR B, Child Hlth Programme, Dhaka, Bangladesh

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2006年 / 44卷 / 10期

关键词：

D O I：

10.1128/JCM.01197-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Highly ciprofloxacin-resistant (MIC, 512 mu g/ml) strains of Salmonella enterica serovar Typhi were isolated from the blood of typhoid patients in Dhaka, Bangladesh. The strains were indistinguishable by their antibiograms, biotypes, and variable-number tandem repeat types and had matching point mutations at positions 83 and 87 of the gyrA gene. The isolation of these strains in an area of high endemicity indicates the need for continuous surveillance of antibiotic resistance of S. enterica serovar Typhi and for the rationalized use of ciprofloxacin.

引用

页码：3811 / 3813

页数：3

共 18 条

[1] Mutations responsible for reduced susceptibility to 4-quinolones in clinical isolates of multi-resistant Salmonella typhi in India [J].