Modulation of poly(ADP-ribosylation) in apoptotic cells

被引：85

作者：

Scovassi, AI

Diederich, M

机构：

[1] CNR, Ist Genet Mol, I-27100 Pavia, Italy

[2] Hop Kirchberg, LBMCC, L-2540 Luxembourg, Luxembourg

来源：

BIOCHEMICAL PHARMACOLOGY | 2004年 / 68卷 / 06期

关键词：

poly(ADP-ribosylation); PARP-1; PARG; apoptosis; anticancer therapy; NF-KB;

D O I：

10.1016/j.bcp.2004.04.023

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Poly(ADP-ribosylation) is a post-translational modification of proteins playing a crucial role in DNA repair, replication, transcription and cell death. In this paper, the main features of this process have been reviewed, focusing on the best known poly(ADP-ribose) polymerizing enzyme, PARP-1, a DNA nick-sensor protein that uses P-NAD(+) to form polymers of ADP-ribose. The modulation of poly(ADP-ribosylation) during apoptosis and the possible effects of its inhibition on cell metabolism are discussed. (C) 2004 Elsevier Inc. All rights reserved.

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页码：1041 / 1047

页数：7

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