Benign Lesions Accompanied by Intractable Epilepsy in Children

被引：16

作者：

Alexiou, George A. ^{[1
]}

Varela, Maria ^{[1
]}

Sfakianos, George ^{[1
]}

Prodromou, Neofytos ^{[1
]}

机构：

[1] Childrens Hosp Agia Sofia, Dept Neurosurg, Athens, Greece

来源：

JOURNAL OF CHILD NEUROLOGY | 2009年 / 24卷 / 06期

关键词：

focal epilepsy; epilepsy surgery; cortical dysplasia; neoplasm; CORTICAL DYSPLASIA; TEMPORAL LOBECTOMY; SURGERY; RESECTION; CHILDHOOD; SEIZURES; OUTCOMES;

D O I：

10.1177/0883073808331079

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Epilepsy surgery has been proposed as a safe alternative treatment for intractable epilepsy in children, especially for patients with structural brain abnormalities. We Studied 24 consecutive children who underwent Surgery for intractable epilepsy. There were 12 males and 12 females. The mean age was 6.5 years. The seizures' duration ranged from 6 months to 2 years. The histopathological examination of the resected lesions revealed in 12 cases the presence of a ganglioglioma, in 7 cases dysembryoplastic neuroepithelial tumor, in I case a low grade glioma, in 2 cases cortical dysplasia, and in 2 cases cavernous malformations. In 18 cases, the lesions were located in the temporal lobe and in 6 cases the lesions were extratemporal. After a mean follow-up period of 4.4 years, 79% (19/24) of patients were seizure free. There were no permanent neurological deficits or deaths. surgery for focal epilepsy in children is a safe procedure with favorable results.

引用

页码：697 / 700

页数：4

共 20 条

[1] Temporal lobectomy in children with intractable seizures [J].

Adelson, PD .

PEDIATRIC NEUROSURGERY, 2001, 34 (05) :268-277

[2]

Blümcke I, 2002, J NEUROPATH EXP NEUR, V61, P575

[3] Surgery of epilepsy associated with focal lesions in childhood [J].

Bourgeois, M ;

Sainte-Rose, C ;

Lellouch-Tubiana, A ;

Malucci, C ;

Brunelle, F ;

Maixner, W ;

Cinalli, G ;

Pierre-Kahn, A ;

Renier, D ;

Zerah, M ;

Hirsch, JF ;

Goutières, F ;

Aicardi, J .

JOURNAL OF NEUROSURGERY, 1999, 90 (05) :833-842

[4] Lesionectomy in the pediatric age [J].

Bourgeois, Marie ;

Di Rocco, Federico ;

Sainte-Rose, Christian .

CHILDS NERVOUS SYSTEM, 2006, 22 (08) :931-935

[5] Analysis of different types of resection for pediatric patients with temporal lobe epilepsy [J].

Clusmann, H ;

Kral, T ;

Gleissner, U ;

Sassen, R ;

Urbach, H ;

Blümcke, I ;

Bogucki, J ;

Schramm, J .

NEUROSURGERY, 2004, 54 (04) :847-859

[6] Epilepsy surgery in children: Results and predictors of outcome on seizures [J].

Cossu, Massimo ;

Lo Russo, Giorgio ;

Francione, Stefano ;

Mai, Roberto ;

Nobili, Lino ;

Sartori, Ivana ;

Tassi, Laura ;

Citterio, Alberto ;

Colombo, Nadia ;

Bramerio, Manuela ;

Galli, Carlo ;

Castana, Laura ;

Cardinale, Francesco .

EPILEPSIA, 2008, 49 (01) :65-72

[7] Imaging and epilepsy [J].

Duncan, JS .

BRAIN, 1997, 120 :339-377

[8] Surgical treatment sf epilepsy in tuberous sclerosis - Strategies and results in 18 patients [J].

Guerreiro, MM ;

Andermann, F ;

Andermann, E ;

Palmini, A ;

Hwang, P ;

Hoffman, HJ ;

Otsubo, H ;

Bastos, A ;

Dubeau, F ;

Snipes, GJ ;

Olivier, A ;

Rasmussen, T .

NEUROLOGY, 1998, 51 (05) :1263-1269

[9] Cortical dysplastic lesions in children with intractable epilepsy: role of complete resection [J].

Hader, WJ ;

Mackay, M ;

Otsubo, H ;

Chitoku, S ;

Weiss, S ;

Becker, L ;

Snead, OC ;

Rutka, JT .

JOURNAL OF NEUROSURGERY, 2004, 100 (02) :110-117

[10] Outcomes after surgery for focal epilepsy in children [J].

Kan, Peter ;

Van Orman, Colin ;

Kestle, John R. W. .

CHILDS NERVOUS SYSTEM, 2008, 24 (05) :587-591

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