Systems Biology Strikes Gold

被引：17

作者：

Camacho, Diogo M. ^{[1
,2
]}

Collins, James J. ^{[1
,2
]}

机构：

[1] Boston Univ, Ctr BioDynam, Dept Biomed Engn, Howard Hughes Med Inst, Boston, MA 02215 USA

[2] Boston Univ, Ctr Appl Biotechnol, Boston, MA 02215 USA

来源：

CELL | 2009年 / 137卷 / 01期

关键词：

NETWORKS;

D O I：

10.1016/j.cell.2009.03.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Integrating synthetic biology and systems biology efforts can advance our understanding of biomolecular systems. This is illustrated in this issue by Cantone et al. (2009), who construct a synthetic gene network in yeast and use it to assess and benchmark systems biology approaches for reverse engineering endogenous gene networks.

引用

页码：24 / 26

页数：4

共 9 条

[1] Learning biological networks: from modules to dynamics [J].

Bonneau, Richard .

NATURE CHEMICAL BIOLOGY, 2008, 4 (11) :658-664

[2] Comparison of reverse-engineering methods using an in Silico network [J].

Camacho, Diogo ;

Licona, Paola Vera ;

Mendes, Pedro ;

Laubenbacher, Reinhard .

REVERSE ENGINEERING BIOLOGICAL NETWORKS: OPPORTUNITIES AND CHALLENGES IN COMPUTATIONAL METHODS FOR PATHWAY INFERENCE, 2007, 1115 :73-89

[3] Chemogenomic profiling on a genomewide scale using reverse-engineered gene networks [J].

di Bernardo, D ;

Thompson, MJ ;

Gardner, TS ;

Chobot, SE ;

Eastwood, EL ;

Wojtovich, AP ;

Elliott, SJ ;

Schaus, SE ;

Collins, JJ .

NATURE BIOTECHNOLOGY, 2005, 23 (03) :377-383

[4] Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles [J].

Faith, Jeremiah J. ;

Hayete, Boris ;

Thaden, Joshua T. ;

Mogno, Ilaria ;

Wierzbowski, Jamey ;

Cottarel, Guillaume ;

Kasif, Simon ;

Collins, James J. ;

Gardner, Timothy S. .

PLOS BIOLOGY, 2007, 5 (01) :54-66

[5] Inferring genetic networks and identifying compound mode of action via expression profiling [J].

Gardner, TS ;

di Bernardo, D ;

Lorenz, D ;

Collins, JJ .

SCIENCE, 2003, 301 (5629) :102-105

[6] Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death [J].

Kohanski, Michael A. ;

Dwyer, Daniel J. ;

Wierzbowski, Jamey ;

Cottarel, Guillaume ;

Collins, James J. .

CELL, 2008, 135 (04) :679-690

[7] A network biology approach to aging in yeast [J].

Lorenz, David R. ;

Cantor, Charles R. ;

Collins, James J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (04) :1145-1150

[8] Modeling turbulent flow with implicit LES [J].

Margolin, LG ;

Rider, WJ ;

Grinstein, FF .

JOURNAL OF TURBULENCE, 2006, 7 (15) :1-27

[9] Advances to Bayesian network inference for generating causal networks from observational biological data [J].

Yu, J ;

Smith, VA ;

Wang, PP ;

Hartemink, AJ ;

Jarvis, ED .

BIOINFORMATICS, 2004, 20 (18) :3594-3603

← 1 →