Regulation by c-Myc of ncRNA expression

被引：21

作者：

Kenneth, Niall S. ^{[1
]}

White, Robert J. ^{[1
,2
]}

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 01期

关键词：

RNA-POLYMERASE-III; TRANSCRIPTIONAL ACTIVATION; HYPERTROPHIC GROWTH; RDNA TRANSCRIPTION; I TRANSCRIPTION; NONCODING RNAS; RIBOSOMAL DNA; HUMAN CANCERS; HEAT-SHOCK; MAX;

D O I：

10.1016/j.gde.2008.11.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Deregulated activity of the proto-oncogene product c-Myc is instrumental in promoting many human cancers. As it is a transcription factor, priority has been given to identifying the genes that it regulates. Until recently, all the attention was focused on protein-encoding genes. It is now clear, however, that c-Myc also controls the production of many non-coding (nc) RNAs, including tRNA, rRNA and miRNAs. This involves it regulating the transcriptional activity of three different RNA polymerases. These ncRNAs are likely to contribute substantially to the complex biology and pathology that is associated with c-Myc.

引用

页码：38 / 43

页数：6

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