Synthesis of (2S,3R,4E,8E)-9-methyl-4,8-sphingadienine via a novel SN2′ type reaction mediated by a thioether carbanion

被引：7

作者：

Wang, XZ

Wu, YL

Jiang, SD

Singh, G

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod, Shanghai 200032, Peoples R China

[2] Univ Sunderland, Dept Chem, Sunderland SR1 3SD, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(99)01885-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of sphingadienine 3 as a new analogue of sphingosine has been achieved by a novel copper-catalyzed S(N)2' type homoallylic coupling reaction between an allylic mesylate and a thioether-stabilized allylic carbanion. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8911 / 8914

页数：4

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