Desymmetrisation of prochiral ketones by catalytic enantioselective hydrolysis of their enol esters using enzymes.

被引：13

作者：

Carnell, AJ

Barkley, J

Singh, A

机构：

[1] Department of Chemistry, Robert Robinson Laboratories, University of Liverpool

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(97)01817-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Desymmetrisation of 4-cyano-4-phenylcyclohexanone 1 has been achieved by enzyme-catalysed enantioselective alcoholysis with n-butanol of the derived racemic enol acetate 2 in tetrahydrofuran. The absolute configuration of the enol acetate (-)-(S)-2 (100% e.e.) obtained was determined by X-ray analysis of the camphanyl derivative 7. (C) 1997 Elsevier Science Ltd.

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页码：7781 / 7784

页数：4

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