Th1 immune response to H. pylori infection varies according to the age of the patients and influences the gastric inflammatory patterns

被引：39

作者：

de Melo, Fabricio Freire ^{[1
,2
]}

Rocha, Gifone Aguiar ^{[1
]}

Camargos Rocha, Andreia Maria ^{[1
]}

Teixeira, Kadima Nayara ^{[1
]}

Souza Pietra Pedroso, Silvia Helena ^{[1
]}

Pereira Junior, Joao Bosco ^{[1
]}

Fonseca de Castro, Lucia Porto ^{[3
]}

Demas Alvares Cabral, Monica Maria ^{[3
]}

Carvalho, Simone Diniz ^{[4
]}

Souto Bittencourt, Paulo Fernando ^{[4
]}

de Oliveira, Celso Afonso ^{[1
]}

de Magalhaes Queiroz, Dulciene Maria ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Fac Med, Lab Res Bacteriol, Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Fac Med, Dept Pathol, Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, Univ Hosp, Endoscopy Serv, Belo Horizonte, MG, Brazil

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2014年 / 304卷 / 3-4期

关键词：

Helicobacter pylori; Cytokines; Children; Adults; Innate immune response; Adaptive immune response; HELICOBACTER-PYLORI; EXPRESSION; CHILDREN; RISK; ANTRUM;

D O I：

10.1016/j.ijmm.2013.11.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

To compare children and adults in respect to the effect of H. pylori infection on the gastric concentrations of cytokines linked to innate and Th1 immune response, as well as to investigate the changes in the gastric concentrations of the studied cytokines according to the age. We studied 245 children (142 H. pylori-negative and 103 H. pylori-positive) and 140 adults (40 H. pylori-negative and 100 H. pylori-positive). The gastric concentrations of cytokines representative of the innate and Th1 response were higher in the H. pylori-positive than in the -negative children and adults. The gastric concentrations of IL-1 alpha and TNF-alpha were significantly higher, while those of IL-2, IL-12p70 and IFN-gamma were lower in the infected children than in the infected adults. In the infected children, the gastric concentration of IL-1 alpha, IL-2, IL-12p70 and IFN-gamma increased, whereas in adults, the gastric concentrations of IFN-gamma and IL-12p70 decreased with the aging. Increased gastric concentration of Th1 associated cytokines correlated with increased degree of gastritis that is the background lesion for the development of the H. pylori associated severe diseases. Concluding, Th1 response to H. pylori infection varies according to the age and seems to have determinant implication in the H. pylori infection outcomes. (C) 2013 Elsevier GmbH. All rights reserved.

引用

页码：300 / 306

页数：7

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