Neisseria lactamica protects against experimental meningococcal infection

被引：71

作者：

Oliver, KJ

Reddin, KM

Bracegirdle, P

Hudson, MJ

Borrow, R

Feavers, IM

Robinson, A

Cartwright, K

Gorringe, AR ^{[1
]}

机构：

[1] Publ Hlth Lab Serv, Ctr Appl Microbiol & Res, Salisbury SP4 0JG, Wilts, England

[2] Withington Hosp, Meningococcal Reference Unit, Manchester Publ Hlth Lab, Manchester M20 2LR, Lancs, England

[3] Gloucestershire Royal Hosp, Publ Hlth Lab, Gloucester GL1 3NN, England

[4] Natl Inst Biol Stand & Controls, Potters Bar EN6 3QG, Herts, England

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 07期

关键词：

D O I：

10.1128/IAI.70.7.3621-3626.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunological and epidemiological evidence suggests that the development of natural immunity to meningococcal disease results from colonization of the nasopharynx by commensal Neisseria spp., particularly with N. lactamica. We report here that immunization with N. lactamica killed whole cells, outer membrane vesicles, or outer membrane protein (OMP) pools and protected mice against lethal challenge by a number of diverse serogroup B and C meningococcal isolates in a model of bacteremic infection. Sera raised to N. Zactamica killed whole cells, OMPs, or protein pools were found to cross-react with meningococcal isolates of a diverse range of genotypes and phenotypes. The results confirm the potential of N. lactamica to form the basis of a vaccine against meningococcal disease.

引用

页码：3621 / 3626

页数：6

共 30 条

[1]

Abdillahi H, 1988, J Med Microbiol, V26, P177

[2] IMMUNOGENICITY AND CROSS-REACTIVITY OF THE 70-KDA IRON-REGULATED PROTEIN OF NEISSERIA-MENINGITIDIS IN MAN AND ANIMALS [J].