Differential utilization of two ATP-generating pathways is regulated by p53

被引：44

作者：

Assaily, Wissam ^{[1
]}

Benchimol, Samuel

机构：

[1] York Univ, Dept Biol, N York, ON M3J 1P3, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

来源：

CANCER CELL | 2006年 / 10卷 / 01期

关键词：

D O I：

10.1016/j.ccr.2006.06.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A fundamental property of cancer cells is the preferential utilization of glycolysis over aerobic respiration to produce ATP. Renewed interest in understanding the mechanism underlying this metabolic shift in energy production is broadening our understanding of the relationship between cancer and cellular metabolism. In a recent article, Matoba et al. report that the p53 tumor suppressor regulates the expression of SCO2, a protein that is required for the assembly of cytochrome c oxidase (COX), a multimeric protein complex required for oxidative phosphorylation. The implication of these findings is that aerobic respiration is compromised in cells that lack functional p53.

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页码：4 / 6

页数：3

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