Clinical management of BRCA1 and BRCA2 mutation carriers

被引：48

作者：

Domchek, S. M.

Weber, B. L.

机构：

[1] Univ Penn, Abramson Canc Ctr, Canc Risk Evaluat Program, Philadelphia, PA 19104 USA

[2] GlaxoSmithKline Inc, Philadelphia, PA USA

来源：

ONCOGENE | 2006年 / 25卷 / 43期

关键词：

BRCA1; BRCA2; oophorectomy; breast cancer; ovarian cancer; management;

D O I：

10.1038/sj.onc.1209881

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cancer susceptibility genes BRCA1 and BRCA2 appear to be responsible for virtually all hereditary breast ovarian families, and a smaller subset of hereditary site-specific breast cancer families. Fortunately, effective strategies have been developed to reduce the risk for the development of breast and ovarian cancer in women with BRCA1/2 mutations, making genetic testing for these mutations an important part of the management at women with a strong family history of these diseases. Here, we review the current evidence for risk reduction strategies and outline future research directions.

引用

页码：5825 / 5831

页数：7

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