Genetic code origin:: Are the pathways of type Glu-tRNAGln→Gln-tRNAGln molecular fossils or not?

被引：43

作者：

Di Giulio, M ^{[1
]}

机构：

[1] CNR, Int Inst Genet & Biophys, I-80125 Naples, Italy

来源：

JOURNAL OF MOLECULAR EVOLUTION | 2002年 / 55卷 / 05期

关键词：

precursor/product amino acids; unusual biosynthetic pathways; molecular fossils; coevolution theory; genetic code origin; RNA world;

D O I：

10.1007/s00239-002-2357-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A logical-evolutionary analysis is conducted to clarify whether or not pathways of type Glu-tRNA(Gln) --> Gln-tRNA(Gln) are molecular fossils of the mechanism that gave rise to the evolutionary organization of the genetic code. The result of this analysis is that these pathways are most likely a manifestation of this mechanism. This provides strong evidence in favor of the coevolution theory of genetic code origin, as this theory is based on the amino acid biosynthetic transformation taking place on tRNA-like molecules which imprinted the genetic code structuring. Comments on the different interpretations of these pathways found in the literature are also provided.

引用

页码：616 / 622

页数：7

共 63 条

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