Chronic but not acute nicotine treatment reverses stress-induced impairment of LTP in anesthetized rats

被引:21
作者
Aleisa, A. M.
Alzolubi, K. H.
Alkadhi, K. A. [1 ]
机构
[1] Univ Houston, Coll Pharm, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA
[2] Jordan Univ Sci & Technol, Coll Pharm, Dept Clin Pharm, Irbid, Jordan
关键词
anesthetized rat; nicotine; chronic; acute; LTP; I/O curve;
D O I
10.1016/j.brainres.2006.04.070
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Stress impairs long-term potentiation (LTP) and is a major cause for starting or increasing tobacco smoking. We have previously shown that chronic concurrent nicotine treatment prevents stress-induced LTP impairment. Nicotine reduces stress-induced impairment of LTP, probably, through activation of nicotinic acetylcholine receptors in the hippocampus. Herein, we investigated the effects of acute and chronic nicotine treatments on the chronic-tress-induced impairment of LTP in area CA1 of the hippocampus of urethane-anesthetized rats. Extracellular in vivo recording from the hippocampal area CA1 showed that pre-treatment with nicotine (1 mg/kg; sc twice/day for 2 weeks prior to stress) protected LTP from the inhibitory effect of subsequent chronic psychosocial stress (4 additional weeks concurrently with nicotine). In another series of experiments, 2 weeks of psychosocial stress was followed by 4 weeks of nicotine treatment concurrently with continuing stress. Nicotine treatment reversed established stress-induced impairment of LTP. However, acute nicotine treatment of rats (a single dose of 1 mg/kg; sc.) did not reverse chronic-stress-induced impairment of LTP. The results show that the impairment of LTP during chronic stress can be blocked by chronic, but not acute, nicotine treatment. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:78 / 84
页数:7
相关论文
共 42 条
[1]   Nicotine prevents stress-induced enhancement of long-term depression in hippocampal area CA1: Electrophysiological and molecular studies [J].
Aleisa, AM ;
Alzoubi, KH ;
Alkadhi, KA .
JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 83 (02) :309-317
[2]  
ALEISA AM, NEUROBIOLOGY DIS
[3]  
ALEISA AM, IN PRESS INT J NEURO
[4]   Psychosocial stress-induced hypertension results from in vivo expression of long-term potentiation in rat sympathetic ganglia [J].
Alkadhi, KA ;
Alzoubi, KH ;
Aleisa, AM ;
Tanner, FL ;
Nimer, AS .
NEUROBIOLOGY OF DISEASE, 2005, 20 (03) :849-857
[5]   COMPARATIVE ALTERATIONS OF NICOTINIC AND MUSCARINIC BINDING-SITES IN ALZHEIMERS AND PARKINSONS DISEASES [J].
AUBERT, I ;
ARAUJO, DM ;
CECYRE, D ;
ROBITAILLE, Y ;
GAUTHIER, S ;
QUIRION, R .
JOURNAL OF NEUROCHEMISTRY, 1992, 58 (02) :529-541
[6]   Smoking rates in the staff of a military field hospital before and after wartime deployment [J].
Boos, CJ ;
Croft, AM .
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 2004, 97 (01) :20-22
[7]   The human hippocampus and spatial and episodic memory [J].
Burgess, N ;
Maguire, EA ;
O'Keefe, J .
NEURON, 2002, 35 (04) :625-641
[8]   Effect of prolonged nicotine infusion on response of rat catecholamine biosynthetic enzymes to restraint and cold stress [J].
Cheng, SY ;
Glazkova, D ;
Serova, L ;
Sabban, EL .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2005, 82 (03) :559-568
[9]   Competitive interactions between endogenous LTD and LTP in the hippocampus underlie the storage of emotional memories and stress-induced amnesia [J].
Diamond, DM ;
Park, CR ;
Campbell, AM ;
Woodson, JC .
HIPPOCAMPUS, 2005, 15 (08) :1006-1025
[10]  
DIAMOND DM, 1994, ANN NY ACAD SCI, V746, P411