Breast Cancer Stem Cells and the Immune System: Promotion, Evasion and Therapy

被引：39

作者：

Boyle, Sarah T. ^{[1
]}

Kochetkova, Marina ^{[1
]}

机构：

[1] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA, Australia

来源：

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA | 2014年 / 19卷 / 02期

基金：

英国医学研究理事会;

关键词：

Breast cancer; Cancer stem cells; Immune system; Chemokine; Cytokine; Immunotherapy; EPITHELIAL-MESENCHYMAL TRANSITION; REGULATORY T-CELLS; LYMPH-NODE METASTASIS; TUMOR-GROWTH; FIBROBLASTS PROMOTE; STROMAL FIBROBLASTS; UP-REGULATION; IN-VITRO; CXCR4; MACROPHAGES;

D O I：

10.1007/s10911-014-9323-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer stem cells are believed to be a subset of heterogeneous tumour cells responsible for tumour initiation, growth, local invasion, and metastasis. In breast cancer, numerous factors have been implicated in regulation of cancer stem cells, but there is still a paucity of information regarding precise molecular and cellular mechanisms guiding their pathobiology. Components of both the adaptive and the innate immune system have been shown to play a crucial role in supporting breast cancer growth and spread, and recently some immune mediators, both molecules and cells, have been reported to influence breast cancer stem cell biology. This review summarises a small, pioneering body of evidence for the potentially important function of the "immuniche" in maintaining and supporting breast cancer stem cells.

引用

页码：203 / 211

页数：9

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