Evidence for a T-lymphocyte dependent mechanism involving proinflammatory cytokines in anticonvulsant hypersensitivity syndrome: A case report.

被引：23

作者：

Chiappini, E ^{[1
]}

Peruzzi, M ^{[1
]}

Galli, L ^{[1
]}

Calabri, G ^{[1
]}

de Martino, M ^{[1
]}

机构：

[1] Univ Florence, Anna Meyer Childrens Hosp, Dept Paediat, Div Paediat & Infect Dis, I-50132 Florence, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2002年 / 15卷 / 03期

关键词：

anticonvulsant hypersensitivity syndrome; phenobarbital; interleukin-6; T-lymphocytes;

D O I：

10.1177/039463200201500311

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anticonvulsant drug hypersensitivity syndrome (AHS) is a potentially fatal drug reaction associated with aromatic antiepileptic drugs, the pathogenic mechanisms of which are still unclear. We studied a 2-year-old female affected with AHS after phenobarbital treatment. In vitro experiments showed a T-lymphocyte response to the drug and an increased, dose-related, IL-6 production after drug incubation. These findings suggest that AHS may be caused by a T-lymphocyte dependent mechanism, involving pro-inflammatory cytokines.

引用

页码：239 / 242

页数：4

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