Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients

被引：212

作者：

Recker, R ^{[1
]}

Lappe, J ^{[1
]}

Davies, KM ^{[1
]}

Heaney, R ^{[1
]}

机构：

[1] Creighton Univ, Creighton Osteoporosis Res Ctr, Omaha, NE 68178 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 10期

关键词：

osteoporosis; bone remodeling rate; menopause; skeletal fragility; histomorphometry;

D O I：

10.1359/JBMR.040710

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bone remodeling rates (Ac.f) were measured in transilial biopsy specimens from 50 healthy premenopausal women before and 1 year after menopause, in 34 healthy women 13 years past menopause, and in 89 women with untreated osteoporosis. Ac.f nearly doubled 1 year after menopause, tripled 13 years after menopause, and remained elevated in women with osteoporosis.

引用

页码：1628 / 1633

页数：6

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