Clastic cells: Mineralized tissue resorption in health and disease

被引：49

作者：

Arana-Chavez, Victor E. ^{[1
]}

Bradaschia-Correa, Vivian ^{[1
]}

机构：

[1] Univ Sao Paulo, Lab Mineralized Tissue Biol, Dept Cell & Dev Biol, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2009年 / 41卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

Clastic cells; Osteoclast; Odontoclast; Resorption; OSTEOCLAST DIFFERENTIATION; BONE; OSTEOPROTEGERIN; LIGAND; RANKL;

D O I：

10.1016/j.biocel.2008.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Clastic cells are responsible for mineralized tissue resorption. Bone resorbing cells are called osteo-clasts; however, they are able to resorb mineralized dental tissues or calcified cartilage and then they are called odontoclasts and chondroclasts, respectively. They derive from mononuclear precursors of the monocyte-macrophage lineage from hemopoietic tissue, reach target mineralized tissues and degrade them under many different physiologic or pathologic stimuli. Clastic cells play a key role in calcium homeostasis, and participate in skeletal growth, tooth movement, and other physiological and pathological events. They interact tightly with forming cells in bone and dental hard tissues; their unbalance may result in disturbed resorptive activity thus, causing local or systemic diseases. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：446 / 450

页数：5

共 20 条

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