NSAID-related upper gastrointestinal bleeding: are risk factors considered during prophylaxis?

被引：24

作者：

Dincer, D ^{[1
]}

Duman, A

Dikici, H

Arici, C

Suleymanlar, I

Isitan, F

机构：

[1] Akdeniz Univ, Fac Med, Div Gastroenterol, TR-07059 Antalya, Turkey

[2] Akdeniz Univ, Fac Med, Div Surg, TR-07059 Antalya, Turkey

来源：

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2006年 / 60卷 / 05期

关键词：

NSAID; upper gastrointestinal bleeding;

D O I：

10.1111/j.1742-1241.2006.00794.x

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The purposes of this study were to evaluate the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on acute nonvaricose upper gastrointestinal bleeding (ANUGIB) and establish whether the NSAID-prescribing physicians take precautions to prevent or reduce GI ulcerations. Clinical characteristics, causes of bleeding and clinical outcomes of patients hospitalised in our gastroenterology clinic with ANUGIB were recorded prospectively over a 1.5-year period. NSAIDs, including aspirin, were used by 127 of 168 patients (73%). Among the NSAID users, 100 patients (78%) had at least one risk factor for serious adverse GI events related to NSAIDs. Only two patients were using proton pump inhibitors and one patient was using H-2 receptor blocker of the high-risk group for GI side effects of NSAIDs. NSAIDs have an important effect on GI bleeding, and it seems that risk factors are underestimated by physicians.

引用

页码：546 / 548

页数：3

共 17 条

[1]

Seroprevalence and some correlates of Helicobacter pylori at adult ages in Gulveren Health District, Ankara, Turkey [J].

Akin, L ;

Tezcan, S ;

Hascelik, G ;

Cakir, B .

EPIDEMIOLOGY AND INFECTION, 2004, 132 (05) :847-856

[2]

Altman RD, 2000, ARTHRITIS RHEUM-US, V43, P1905

[3]

Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials [J].

Deeks, JJ ;

Smith, LA ;

Bradley, MD .

BRITISH MEDICAL JOURNAL, 2002, 325 (7365) :619-623

[4]

GRAHAM DY, 1988, LANCET, V2, P1277

[5]

Ulcer prevention in long-term users of nonsteroidal anti-inflammatory drugs - Results of a double-blind, randomized,, multicenter, active- and placebo-controlled study of misoprostol vs lansoprazole [J].

Graham, DY ;

Agrawal, NM ;

Campbell, DR ;

Haber, MM ;

Collis, C ;

Lukasik, NL ;

Huang, B .

ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (02) :169-175

[6]

DUODENAL AND GASTRIC-ULCER PREVENTION WITH MISOPROSTOL IN ARTHRITIS PATIENTS TAKING NSAIDS [J].

GRAHAM, DY ;

WHITE, RH ;

MORELAND, LW ;

SCHUBERT, TT ;

KATZ, R ;

JASZEWSKI, R ;

TINDALL, E ;

TRIADAFILOPOULOS, G ;

STROMATT, SC ;

TEOH, LS .

ANNALS OF INTERNAL MEDICINE, 1993, 119 (04) :257-262

[7]

*IMS HLTH, 2000, RET PROV PERSP NAT P

[8]

PREVENTION OF NSAID-INDUCED GASTRODUODENAL MUCOSAL INJURY - METAANALYSIS OF CLINICAL-TRIALS WITH MISOPROSTOL AND H-2-RECEPTOR ANTAGONISTS [J].

KOCH, M ;

CAPURSO, L ;

DEZI, A ;

FERRARIO, F ;

SCARPIGNATO, C .

DIGESTIVE DISEASES, 1995, 13 :62-74

[9]

A randomized trial comparing the effect of rofecoxib, a cyclooxygenase 2-specific inhibitor, with that of ibuprofen on the gastroduodenal mucose of patients with osteoarthritis [J].

Laine, L ;

Harper, S ;

Simon, T ;

Bath, R ;

Johanson, J ;

Schwartz, H ;

Stern, S ;

Quan, H ;

Bolognese, J .

GASTROENTEROLOGY, 1999, 117 (04) :776-783

[10]

Approaches to nonsteroidal anti-inflammatory drug use in the high-risk patient [J].

Laine, L .

GASTROENTEROLOGY, 2001, 120 (03) :594-606

← 1 2 →