Adenosine-Mediated Effects of Ticagrelor Evidence and Potential Clinical Relevance

被引：258

作者：

Cattaneo, Marco ^{[1
]}

Schulz, Rainer ^{[2
]}

Nylander, Sven ^{[3
]}

机构：

[1] Univ Milan, Osped San Paolo, Dipartimento Sci Salute, Unita Med 3, I-20142 Milan, Italy

[2] Univ Giessen, Inst Physiol, D-35390 Giessen, Germany

[3] AstraZeneca Res & Dev, Molndal, Sweden

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2014年 / 63卷 / 23期

关键词：

acute coronary syndrome(s); adenosine; antiplatelet agents; P2Y12; ticagrelor; ACUTE CORONARY SYNDROME; TARGETED DELETION; P2Y(12) RECEPTOR; A(3) RECEPTORS; INFARCT SIZE; PLATO TRIAL; CLOPIDOGREL; DYSPNEA; DIPYRIDAMOLE; MORTALITY;

D O I：

10.1016/j.jacc.2014.03.031

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

This review constitutes a critical evaluation of recent publications that have described an additional mode of action of the P2Y(12) receptor antagonist ticagrelor. The effect is mediated by inhibition of the adenosine transporter ENT1 (type 1 equilibrative nucleoside transporter), which provides protection for adenosine from intracellular metabolism, thus increasing its concentration and biological activity, particularly at sites of ischemia and tissue injury where it is formed. Understanding the mode of action of ticagrelor is of particular interest given that its clinical profile, both in terms of efficacy and adverse events, differs from that of thienopyridine P2Y(12) antagonists. (c) 2014 by the American College of Cardiology Foundation

引用

页码：2503 / 2509

页数：7

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