Post-study caffeine administration enhances memory consolidation in humans

被引：152

作者：

Borota, Daniel ^{[1
]}

Murray, Elizabeth ^{[1
]}

Keceli, Gizem ^{[2
]}

Chang, Allen ^{[1
]}

Watabe, Joseph M. ^{[1
]}

Ly, Maria ^{[1
]}

Toscano, John P. ^{[2
]}

Yassa, Michael A. ^{[1
,3
]}

机构：

[1] Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

[3] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 02期

基金：

美国国家科学基金会;

关键词：

INHIBITORY AVOIDANCE MEMORY; PATTERN SEPARATION; HIPPOCAMPUS; DECLINE; RATS; MICE;

D O I：

10.1038/nn.3623

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.

引用

页码：201 / 203

页数：3

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