Mycobacterium and the coat of many lipids

被引：125

作者：

Russell, DG ^{[1
]}

Mwandumba, HC

Rhoades, EE

机构：

[1] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Vet Med Ctr 5 173, Ithaca, NY 14853 USA

[2] Wellcome Res Labs, Blantyre 3, Malawi

来源：

JOURNAL OF CELL BIOLOGY | 2002年 / 158卷 / 03期

基金：

英国惠康基金;

关键词：

mycobacterium; macrophage; phagosome; tuberculosis; lipidoglycan;

D O I：

10.1083/jcb.200205034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pathogenic Mycobacterium reside inside vacuoles in their host macrophages. These vacuoles fail to fuse with lysosomes yet interact with early endosomes. Glycoconjugates released by the intracellular bacilli traffic through the host cell and are released through exocytosis. These molecules represent both antigens for immune recognition and modulators of immune function. The molecules play key roles in the induction and maintenance of the granuloma, a tissue response that limits bacterial spread yet ensures persistence of the infection.

引用

页码：421 / 426

页数：6

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