Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1

被引：33

作者：

Boyan, Barbara D.

Wong, Kevin L.

Wang, Liping

Yao, Hai

Guldberg, Robert E.

Drab, Marek

Jo, Hanjoong

Schwartz, Zvi

机构：

[1] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[2] Georgia Inst Technol, Dept Mech Engn, Atlanta, GA 30332 USA

[3] Max Planck Inst Infect Biol, Berlin, Germany

[4] Hebrew Univ Jerusalem, Dept Periodont, Jerusalem, Israel

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 10期

关键词：

caveolae; caveolin-1; 1,25-dihydroxyvitamin D-3; ERp60; chondrocytes; protein kinase C; mu CT; Cav-1 knockout mice;

D O I：

10.1359/JBMR.060713

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We examined the role of caveolae and caveolin-1 in the mechanism of 1 alpha,25(OH)(2)D-3 action in growth plate chondrocytes. We found that caveolae are required for rapid 1 alpha,25(OH)A-dependent PKC signaling, and caveolin-1 must be present based on studies using chondrocytes from Cav-1(-/-) mice.

引用

收藏

页码：1637 / 1647

页数：11

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