Vanishing bile duct syndrome associated with chronic EBV infection

被引：28

作者：

Kikuchi, K ^{[1
]}

Miyakawa, H ^{[1
]}

Abe, K ^{[1
]}

Fujikawa, H ^{[1
]}

Horiuchi, T ^{[1
]}

Nagai, K ^{[1
]}

Kako, M ^{[1
]}

机构：

[1] Teikyo Univ, Sch Med, Dept Internal Med 4, Kanagawa 2138507, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2000年 / 45卷 / 01期

关键词：

bile duct loss; Epstein-Barr virus; in situ hybridization; HLA class II molecule;

D O I：

10.1023/A:1005434015863

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We reported here an adult patient with vanishing bile duct syndrome due to chronic EBV infection. A 22-year-old male was admitted to a nearby hospital complaining of a sore throat and jaundice. He received a high dose of prednisolone for bile stasis of acute viral hepatitis. However, the hepatitis did not improve, and he was transferred to our hospital. He had exhibited jaundice for one year as well as hemophagocytic syndrome and intestinal perforation. Subtotal intestinal resection was successfully performed. Three follow-up biopsied liver specimens indicated vanishing bile duct syndrome. Positive results of EBV-DNA in his serum and mRNA of EBV by in situ hybridization of his liver indicated that massive doses of prednisolone caused chronic EBV infection and vanishing bile duct syndrome.

引用

页码：160 / 165

页数：6

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