Mechanisms of neonatal mucosal antibody protection

被引:163
作者
Harris, Nicola L.
Spoerri, Iris
Schopfer, Jacqueline F.
Nembrini, Chiara
Merky, Patrick
Massacand, Joanna
Urban, Joseph F., Jr.
Lamarre, Alain
Burki, Kurt
Odermatt, Bernhard
Zinkernagel, Rolf M.
Macpherson, Andrew J.
机构
[1] Swiss Fed Inst Technol, Inst Integrat Biol, CH-8952 Zurich, Switzerland
[2] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland
[3] USDA, Nutrient Requirements & Funct Lab, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA
[4] Univ Quebec, Inst Armand Frappier, INSERM, Laval, PQ, Canada
[5] McMaster Univ, Med Ctr, Dept Med, Hamilton, ON L8N 3Z5, Canada
关键词
FC-RECEPTOR; IGA RESPONSES; CELL-LINE; B-CELLS; TRANSPORT; MICE; EXPRESSION; INFECTION; ANTIGENS; SYSTEM;
D O I
10.4049/jimmunol.177.9.6256
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Following an abrupt transition at birth from the sterile uterus to an environment with abundant commensal and pathogenic microbes, neonatal mammals are protected by maternal Abs at mucosal surfaces. We show in mice that different Ab isotypes work in distinct ways to protect the neonatal mucosal surface. Secretory IgA acts to limit penetration of commensal intestinal bacteria through the neonatal intestinal epithelium: an apparently primitive process that does not require diversification of the primary natural Ab repertoire. In contrast, neonatal protection against the exclusively luminal parasite Heligmosomoides polygyrus required IgG from primed females. This immune IgG could either be delivered directly in milk or retrotransported via neonatal Fc receptor from the neonatal serum into the intestinal lumen to exert its protective effect.
引用
收藏
页码:6256 / 6262
页数:7
相关论文
共 31 条
[1]   Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection [J].
Baba, TW ;
Liska, V ;
Hofmann-Lehmann, R ;
Vlasak, J ;
Xu, WD ;
Ayehunie, S ;
Cavacini, LA ;
Posner, MR ;
Katinger, H ;
Stiegler, G ;
Bernacky, BJ ;
Rizvi, TA ;
Schmidt, R ;
Hill, LR ;
Keeling, ME ;
Lu, YC ;
Wright, JE ;
Chou, TC ;
Ruprecht, RM .
NATURE MEDICINE, 2000, 6 (02) :200-206
[2]   Mucosal immunity: integration between mother and the breast-fed infant [J].
Brandtzaeg, P .
VACCINE, 2003, 21 (24) :3382-3388
[3]  
Butler JE, 2005, MUCOSAL IMMUNOLOGY, 3RD EDITION, P1763, DOI 10.1016/B978-012491543-5/50107-8
[4]  
Cascalho M, 1997, J IMMUNOL, V159, P5795
[5]   A quasi-monoclonal mouse [J].
Cascalho, M ;
Ma, A ;
Lee, S ;
Masat, L ;
Wabl, M .
SCIENCE, 1996, 272 (5268) :1649-1652
[6]   IMMUNOGLOBULIN GENE REARRANGEMENT IN B-CELL DEFICIENT MICE GENERATED BY TARGETED DELETION OF THE J(H) LOCUS [J].
CHEN, JZ ;
TROUNSTINE, M ;
ALT, FW ;
YOUNG, F ;
KURAHARA, C ;
LORING, JF ;
HUSZAR, D .
INTERNATIONAL IMMUNOLOGY, 1993, 5 (06) :647-656
[7]   Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human β2-microglobulin [J].
Claypool, SM ;
Dickinson, BL ;
Yoshida, M ;
Lencer, WI ;
Blumberg, RS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (31) :28038-28050
[8]   Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell Line [J].
Dickinson, BL ;
Badizadegan, K ;
Wu, Z ;
Ahouse, JC ;
Zhu, XP ;
Simister, NE ;
Blumberg, RS ;
Lencer, WI .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (07) :903-911
[9]   FcRn: the MHC class I-related receptor that is more than an IgG transporter [J].
Ghetie, V ;
Ward, ES .
IMMUNOLOGY TODAY, 1997, 18 (12) :592-598
[10]  
Hanson LÅ, 2005, MUCOSAL IMMUNOLOGY, 3RD EDITION, P1795, DOI 10.1016/B978-012491543-5/50108-X