Copper and nickel complex-formation equilibria with Lys-Gly-His-Lys, a fragment of the matricellular protein SPARC

被引：33

作者：

Conato, C

Kozlowski, H

Mlynarz, P

Pulidori, F

Remelli, M

机构：

[1] Univ Ferrara, Dept Chem, I-44100 Ferrara, Italy

[2] Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland

来源：

POLYHEDRON | 2002年 / 21卷 / 14-15期

关键词：

copper complexes; nickel complexes; complex-formation equilibria; lysyl-glycyl-histidyl-lysine;

D O I：

10.1016/S0277-5387(02)00952-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Complex-formation equilibria of the tetrapeptide Lys-Gly-His-Lys with the Cu(II) and the Ni(II) ions have been studied in aqueous solution, at I=0.1 mol dm(-3) (KNO3) and T=25degreesC. Protonation and complex-formation constants have been potentiometrically determined. The structure of the main complex species is discussed on the basis of thermodynamic data obtained by direct calorimetry as well as the CD, ESR and electronic spectra. The participation of two amide nitrogens in complex-formation is suggested for both the metal ions, while no evidence supports the participation of the epsilon-NH2 side groups of Lys residues in coordination. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1469 / 1474

页数：6

相关论文

共 19 条

[1] NONCOVALENT INTERACTIONS IN THERMODYNAMIC STEREOSELECTIVITY OF MIXED-LIGAND COPPER(II)-D-HISTIDINE OR L-HISTIDINE COMPLEXES WITH L-AMINO-ACIDS - A POSSIBLE MODEL OF METAL ION-ASSISTED MOLECULAR RECOGNITION [J].

BORGHESANI, G ;

PULIDORI, F ;

REMELLI, M ;

PURRELLO, R ;

RIZZARELLI, E .

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1990, (07) :2095-2100

[2] SPARC, a matricellular protein that functions in cellular differentiation and tissue response to injury [J].

Bradshaw, AD ;

Sage, EH .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (09) :1049-1054

[3] SPARC, a matricellular protein: at the crossroads of cell-matrix [J].

Brekken, RA ;

Sage, EH .

MATRIX BIOLOGY, 2000, 19 (07) :569-580

[4] MOLECULAR DESIGN TO MIMIC COPPER(II) TRANSPORT SITE OF HUMAN-ALBUMIN - CRYSTAL AND MOLECULAR-STRUCTURE OF COPPER(II) - GLYCYLGLYCYL-L-HISTIDINE-N-METHYL AMIDE MONOAQUO COMPLEX [J].

CAMERMAN, N ;

CAMERMAN, A ;

SARKAR, B .

CANADIAN JOURNAL OF CHEMISTRY, 1976, 54 (08) :1309-1316

[5] Copper(II) complexes with L-lysine and L-ornithine:: is the side-chain involved in the coordination?: A thermodynamic and spectroscopic study [J].

Conato, C ;

Contino, A ;

Maccarrone, G ;

Magrì, A ;

Remelli, M ;

Tabbì, G .

THERMOCHIMICA ACTA, 2000, 362 (1-2) :13-23

[6] Copper complexes of glycyl-histidyl-lysine and two of its synthetic analogues: chemical behaviour and biological activity [J].

Conato, C ;

Gavioli, R ;

Guerrini, R ;

Kozlowski, H ;

Mlynarz, P ;

Pasti, C ;

Pulidori, F ;

Remelli, M .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2001, 1526 (02) :199-210

[7] Ni(II) complexes of dipeptides: a thermodynamic and spectroscopic study [J].

Conato, C ;

Ferrari, S ;

Kozlowski, H ;

Pulidori, F ;

Remelli, M .

POLYHEDRON, 2001, 20 (7-8) :615-621

[8] KINETIC AND THERMODYNAMIC STUDIES OF THE COPPER(II) AND NICKEL(II) COMPLEXES OF GLYCYLGLYCYL-L-HISTIDINE [J].

HAY, RW ;

HASSAN, MM ;

CHEN, YQ .

JOURNAL OF INORGANIC BIOCHEMISTRY, 1993, 52 (01) :17-25

[9] Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40 [J].

Hohenester, E ;

Maurer, P ;

Timpl, R .

EMBO JOURNAL, 1997, 16 (13) :3778-3786

[10] SPARC IS A SOURCE OF COPPER-BINDING PEPTIDES THAT STIMULATE ANGIOGENESIS [J].

LANE, TF ;

IRUELAARISPE, ML ;

JOHNSON, RS ;

SAGE, EH .

JOURNAL OF CELL BIOLOGY, 1994, 125 (04) :929-943