Convenient and efficient syntheses of 4-hydroxy-2(E)-nonenal and 4-oxo-2(E)-nonenal

被引：10

作者：

Kurangi, Reshma F. ^{[1
]}

Tilve, Santosh G.

Blair, Ian A.

机构：

[1] Goa Univ, Dept Chem, Taleigao Plateau, Goa, India

[2] Univ Penn, Sch Med, Ctr Canc Pharmacol, Philadelphia, PA 19104 USA

来源：

LIPIDS | 2006年 / 41卷 / 09期

关键词：

D O I：

10.1007/s11745-006-5043-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Lipid peroxidation products 4-hydroxy-2(E)-nonenal (HNE) and 4-oxo-2(E)-nonenal (ONE) were conveniently synthesized using Wittig and Horner-Wardsworth-Emmons (HWE) reaction. Wittig or HWE reaction between an easily prepared phosphorane or phosphonate with glyoxal dimethyl acetal gave a protected 4-oxo-2(E)-nonenal. Hydrolysis gave 4-oxo-2(E)-nonenal, whereas reduction followed by hydrolysis gave 4-hydroxy-2(E)-nonenal.

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收藏

页码：877 / 880

页数：4

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