The synthesis and biological activity of a highly selective adenosine A2a receptor agonist

被引：4

作者：

Borcherding, DR ^{[1
]}

Lentz, NL ^{[1
]}

Weintraub, PM ^{[1
]}

Dudley, MW ^{[1
]}

Secrest, R ^{[1
]}

Kastner, PR ^{[1
]}

Peet, NP ^{[1
]}

机构：

[1] Hoechst Marion Roussel Inc, Bridgewater, NJ 08807 USA

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 10期

关键词：

D O I：

10.1080/07328319908044874

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound I was shown to be the most selective A(2a) receptor agonist reported to date having an A(1)/A(2) ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate.

引用

页码：2175 / 2191

页数：17

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